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United States

Veloci BioPharma Analyzer

A-TEEM Spectroscopy

The Veloci A-TEEM BioPharma Analyzer contains innovative, column-free molecular fingerprinting technology designed for the biopharma and pharma industries. By integrating the selectivity of chromatography with the benefits of optical spectroscopy, Veloci offers a fast, simple, and cost-effective method for comprehensive component analysis in various industrial QC/QA life science applications. Unlike traditional methods such as chromatography and mass spectrometry, Veloci’s A-TEEM™ Molecular Fingerprinting technology provides component analysis without time consuming and slow separations. This allows simplified workflows and drastically reduces ownership costs. This versatile tool requires no sample preparation and is suitable for a wide range of applications, including monoclonal antibody discrimination, cell media monitoring, vaccine characterization, protein stability analysis, and AAV quantification. The Veloci A-TEEM BioPharma Analyzer enables label-free intrinsic fluorescence analysis, offering high accuracy and efficiency in research, production and QC/QA environments.

Segment: Scientific

Abteilung: Fluorescence Spectroscopy

Produktionsfirma: HORIBA Scientific

Key Benefits

Selectivity of chromatography, but using spectroscopy.
Superior sensitivity compared to HPLC/MS and other spectroscopic techniques like absorbance, FTIR, and Raman.
Hassle-free operation with no columns, mobile phase, or sample preparation needed. The lack of a mobile phase drastically reduces solvent usage and eliminates the cost of proper disposal.
Cost-effective and user-friendly: Suitable for both research labs and production processes

Applications

Monoclonal Antibodies (mAb)
AAVs (Adeno-Associated Viruses)
Vaccines
Protein Stability and Aggregation
Antibody-Drug Conjugates
Cell Media Monitoring and Bioreactor Monitoring
Exosomes

EzSpec Software

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Download the Veloci BioPharma Analyzer brochure to learn more

Veloci Biopharma Analyzer
Detection Limit	Parts per billion (sample and wavelength dependent)
Excitation/Absorbance Wavelength Range	200 to 800 nm
Fluorescence Emission Wavelength Range	250 to 800 nm
Wavelength Accuracy	+/- 1 nm
EEM/A-TEEM Acquisition Rate	As fast as 60 seconds (sample and wavelength dependent)
Optional Accessories	Remote fiber optic probe, Autosampler with flow cell
Minimum Sample Volume	70 microliters
Sample Handling, Internal	Cuvette and solid sample holders
Sample Handling, External	Autosampler (96 sample maximum)
Light Source	Xenon arc lamp
Validation	Complies with US Pharmacopia
Dimensions (W x D x H)	24 in x 17 in x 13 in; 618 mm x 435 mm x 336 mm
Weight	32.72 kg (72 lbs.)

scrollable

Characterizing Monoclonal Antibody Purification with 2D Fluorescence Spectroscopy

Fluorescence spectroscopy is widely used in various industries, including life sciences. Two-dimensional (2D) fluorescence excitation-emission matrix (EEM) spectroscopy has been utilized for over 30 years to characterize or “fingerprint” biological samples.

Monitoring Cell Culture Media Variability Using the Veloci and A-TEEM Molecular Fingerprinting

Cell culture media for bioreactors are commonly prepared as aqueous solutions that provide the essential nutrients and conditions required for optimal cell growth, product yield, and quality. Even subtle variations in media composition can significantly impact cell growth rates and yield. Consequently, the identification and analysis of cell culture media are critical for maintaining consistency and optimizing performance.

Monitoring Culture Medium Conditions During Cell Proliferation Using the Veloci BioPharma Analyzer

Monitoring culture media conditions is critical for optimizing cell growth in the Biopharma industry. The health of cells has drastic impacts on the yield and quality of APIs in regenerative medicine, monoclonal antibody production (mAB), protein synthesis, and many more applications.

Simultaneous A-TEEM and UV-Vis Analysis for Insulin Structure and Stability Assessment

Stability and aggregation of insulin are studied using simultaneous fluorescence excitation-emission matrices (EEMs) and UV-Vis absorbance spectroscopy. Insulin is a protein-hormone produced by the pancreas and is necessary for basic metabolic processes. Commercial insulin therapeutics generally fall into two categories: short-acting and long-acting insulin. The difference between some short-acting and long-acting insulin lies, in some cases, in only one to three residues in the protein sequence.

Größe: 6.56 MB

Veloci Brochure

Größe: 4.48 MB

A-TEEM Direktor Brochure

Informationsanfrage

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