Clinical Case 5 - Acute myeloid leukemia type monoblastic (AML-M5b)

Patient demography: Woman, 67 years old
Diagnosis: AML Type monoblastic
Observation: Fortuitous discovery of AML in immediate post surgery with bilateral adnexectomy for ovarian carcinoma in a woman with mutated BRCA1 and no previous treatment. Persistent anemia and thrombopenia, rapid increase in WBC and blast cell appearance in blood led to bone marrow examination confirming the diagnosis of monoblastic AML (81% blast and monoblast).
Other tests information: Hemoglobin 90 G/L, platelet 59 G/L, Leucocytes = Day-1: 3.0 G/L with monocyte 15.7%, Day-3: 3.6 G/L with 12% blast cell and monoblast, 14.1% monocyte and promonocyte, Day-7: 15.8 G/L with 47.3% blast cell and monoblast, 17.3% monocyte and promonocyte; BM Caryotype = normal; BM Molecular genetics = Mutated NPM 1 and FLT 3.
Microscopic count:Monocytes and promonocytes 18.3%; Blast cells and monoblast 52%
Analyzer: Yumizen H2500/H1500
Case provided by: Durrieu Francoise, Institute Bergonie, Bordeaux, France