Pharmacology Toxicology and Pharmacy

Raman Microscopy: A must for pharmaceutical product analysis, from formulation studies to QC

The development of a new drug product is a long road in the pharmaceutical industry. Understanding active pharmaceutical ingredients (APIs) and compound spatial distributions, investigating final product homogeneity, and differentiating chemically similar molecules such as polymorphs are constant challenges when working to guarantee product quality and process efficiency.

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Raman Microscopy: A must for pharmaceutical product analysis, from formulation studies to QC

Find Out More

Raman Microscopy: A must for pharmaceutical product analysis, from formulation studies to QC

Find Out More

Surface-enhanced Raman scattering (SERS) is a powerful plasmonics-based analytical technique for biosensing. SERS effect relies on nanostructures that need to be designed to maximize enhancement factors and molecular specificity. In addition to numerical modeling, an analytical tool capable of imaging localized enhancement would be an added value.

Raman spectroscopy is well known as a powerful analytical method for qualitative chemical analysis. Less well known is that under certain conditions Raman spectroscopy can also be an effective method for quantitative analysis. Here we demonstrate that capability for quantitative analysis under a variety of conditions, involving different solutes in a solution and solution mixtures, and its applications to pharmaceutical analysis such as content uniformity.

Adeno-Associated Viruses (AAVs) are becoming widely used as viral vectors to deliver cell and gene therapies and vaccines. As production methods scale to meet growing demand, more information is needed more quickly.