Biopharma

Fluorescence spectroscopy is widely used in a variety of industries including biological sciences. Two dimensional (2D) fluorescence excitation-emission matrix (EEM) spectroscopy has been described in the literature for over 30 years to characterize or “fingerprint” biological samples.

Disinfecting your hands with hydroalcoholic gel has become a daily practice. In the meanwhile, 70° alcohol has been used for even longer to disinfect wounds. But, to remain efficient, the alcohol concentration of these products must not be below a defined threshold and must be controlled. This application note demonstrates how to evaluate alcohol concentrations in a quality control process with Raman.

Due to the corona crisis, hand sanitizer became part of our daily routine. However, their use is not without potential risks because of their microplastics content. HORIBA offers all the tools necessary to analyze and characterize the presence of Microplastics in hand sanitizers: High-performance Raman microscopes, dedicated filtration kit, and especially the powerful particles detection software ParticleFinder™. We analyzed 3 samples of hand sanitizers, from different countries, and we were able to identify the different plastic content of each.

Exosomes are small extracellular vesicles, 30-150 nm in diameter, which have been determined to play a crucial role in extracellular signaling. They have been observed in both prokaryotic and eukaryotic organisms, meaning they are incredibly widely spread in nature. Exosomes bud off from their parent cells in a sealed package, taking the properties of their parent cell walls with them and encasing many intracellular components.

A virus particle consists of several parts including the genetic material (DNA or RNA), a protein coat that protects these genes, and in some cases an envelope of lipids that surrounds the protein coat when they are outside a cell.

This application note presents data from the SZ-100 using cells with unique, patented carbon coated electrodes that facilitate zeta potential measurements of proteins.

Stability and aggregation of insulin are studied using simultaneous fluorescence excitation emission matrices (EEMs) and UV-Vis absorbance spectroscopy [1]. Insulin is a protein-hormone, produced by the pancreas and is necessary for basic metabolic processes. The different types of commercial insulin therapeutics generally fall into two categories: short-acting and long-acting insulin. The difference between some short-acting and long-acting insulin is, in some cases, only one to three residues in the protein sequence.