February 2024
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Patient Demography: Male, 85 years old
Diagnosis: Anemia with Bi-Cytopenia
Symptoms: Generalized weakness, loss of appetite, low grade fever, weight loss
Microscopic Review: Blast: 4%, Neutrophil: 13%, Eosinophils 1%, Lymphocytes: 16%, Monocytes: 43%, Abnormal monocytes: 14%, Myelocytes: 9%. Dysplasia seen in granulocytic series cells (Degranulation and loss of nuclear segmentation in neutrophil series of cells seen)
How Yumizen Can Assist: On the DIFF scattergram, we observe a population corresponding to the immature cell presence as an overlap in Neutrophils and Monocytic threshold. This is due to the dysplasia noted on the WBC differential. The population is situated between the granulocytic-IMG (on slide microscopy seen as Myelocytes, dysplastic neutrophils) and monocytic-IMM (vacuolated Monocytes) immature cell lines. On the BASO histogram, we observe the immature granulocytic population.
This clinical case has been provided by Dr. Trupti Shetty, Dr. Leena Salunke, Dr. Anupa Dixit, Mr. Manohar, Dept. of Hematology Suburban Diagnostics Reference Laboratory, Mumbai, India.
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