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MacroRAM™

MacroRAM Affordable Benchtop Raman Spectrometer
MacroRAM Benchtop Raman Spectrometer Video
How to set up your MarcoRAM
Spectroscopy on 60 seconds--MacroRAM Accessories and Probes
KnowItAll: Raman Spectral Searching LabSpec 6 Video

Benchtop Raman Spectrometer

MacroRAM™ is an easy-to-use macro Raman spectrometer for fast and reliable Raman analysis. Perfect for bulk analysis of solids, liquid solutions, powders, and gels, MacroRAM provides the flexibility and sensitivity to handle virtually any type of sample. With a compact and robust design including Class 1* laser safety, MacroRAM is ideal for use in most environments, from undergraduate teaching labs to industrial QC and manufacturing.

Powered by the industry-leading LabSpec 6 spectroscopy suite software, MacroRAM brings simplicity to macro Raman spectroscopy without compromising the ability to handle even the most challenging applications. It is ideal for confirming the identity and quality control of incoming raw materials, as well as for analyzing chemical composition, process monitoring, and assessing unknown substances. MacroRAM's durability and fixed internal setup ensure consistent and reproducible results over time, making it a reliable and robust choice for researchers, scientists, and industry professionals across such disciplines as pharmaceuticals, polymers & microplastics, forensics, wet chemistry, gemology, and other industries.

To facilitate the use of the MacroRAM in the undergraduate teaching laboratory setting, a series of educational labs are available. Designed to teach some of the most important concepts in Raman spectroscopy, such as identification, quantification, and vibrational chemistry, these educational labs can be used as is or tailored to fit the needs of any undergraduate laboratory. To learn more about these labs, please visit MacroRAM Educational Labs

Segment: Scientific
Manufacturing Company: HORIBA Scientific

Unlock Rapid, Precise Analysis with the MacroRAM Raman Spectrometer

The MacroRAM Raman Spectrometer is engineered to deliver fast, reliable results across a wide range of applications. Whether you're in a fast-paced industrial setting or a dynamic academic lab, the MacroRAM streamlines your workflow, saving you valuable time and resources.

Key Benefits:

  • Quick, Easy, and Efficient Raman Spectroscopy
    • Raman spectroscopy requires little to no sample preparation, saving you time, money, and consumables, resulting in a low cost of ownership.
    • The simple and easy installation of the MacroRAM and the short warm-up time of less than one minute means you can start measuring samples immediately, eliminating delays and maximizing productivity.
  • Superior Sensitivity and Wide Dynamic Range
    • The high quantum efficiency of the BI-NIR CCD (~4x more QE in the NIR than a standard OE CCD) allows for measurement of the C-H, N-H, and O-H stretching regions, providing more information about the sample than other macroscopic Raman systems on the market. This CCD combined with the high-powered 785 nm laser delivers exceptional sensitivity, allowing for the measurement of low concentration samples.
    • On the other hand, the wide dynamic range of the CCD (55,500:1), combined with the fully adjustable laser power, allows for the measurement of samples of varying concentrations—all on a single system!
  • Safety in Any Environment
    • Safety is paramount in any environment, whether in academia or industry. The MacroRAM offers Class 1 laser safety when using the fully enclosed internal compartment. A lid safety interlock ensures that the laser does not turn on until the lid is completely closed, and turns off immediately once the lid is opened, minimizing any potential safety risks.
    • When using an external fiber coupled probe, multiple external safety interlocks and an internal shutter provide an extra layer of protection, which is particularly important when multiple users operate the system.
  • Robustness and Versatility
    • The compact and robust design of the MacroRAM makes it ideal for both laboratory and field applications, expanding its versatility for various applications.
    • The MacroRAM enables incredibly fast measurements—fractions of seconds—allowing you to track rapidly changing processes in real-time, at-line, in-line, and/or in-process. This is crucial for applications like monitoring polymerization reactions or other dynamic chemical processes.
  • Effortless Operation and Powerful Analysis
    • Our user-friendly LabSpec software simplifies operation, allowing you to obtain spectra with a single press of a button.
    • For advanced data processing and analysis, LabSpec software offers a complete solution to extract the precise information you need from your samples—quickly and effortlessly. And, with seamless integration of spectral database searching software, you can identify materials instantly, all with a single click!
    • The LabSpec software also enables 21 CFR Part 11 compliance to meet FDA guidelines for pharmaceutical applications.
  • Flexible sampling options
    • The MacroRAM offers a wide array of sample holders (cuvette holder, powder/solid holder, external probes, flow cell, temperature drawer, etc.), providing the flexibility to measure all types of samples quickly and easily.
    • The ability to connect external probes extends this versatility, enabling measurements of liquids, larger samples, and other challenging materials through immersion or stand-off techniques.
  • Ideal for Teaching Laboratories
    • In any teaching environment, safety is of utmost importance. The MacroRAM has Class 1 laser safety when measuring in the fully enclosed internal compartment, ensuring the laser cannot be turned on unexpectedly, and minimizing any potential safety risks.
    • To facilitate the use of the MacroRAM in an undergraduate teaching laboratory setting, a series of educational labs are available. To learn more about these labs, please visit MacroRAM Educational Labs

 

Applications Across Diverse Industries

The MacroRAM's versatility makes it ideal for a wide range of applications, including:

  • Pharmaceuticals: Liquid concentrations, contamination analysis, polymorph analysis, real-time analysis, and raw material analysis, all with exceptional sensitivity!
  • Polymers: Identification, differentiation, contamination analysis, and real-time monitoring of polymerization reactions
  • Forensics: Drug and explosives identification, measurements through containers, and fiber identification
  • Industrial Chemicals: Raw materials, monitoring chemical reactions, QC/QA
  • Semiconductor Wet Process: Raw material identification, contamination control, and concentration monitoring
  • Carbons: D/G ratio analysis for quality assessment
  • Battery: Electrolyte characterization
  • Food and Beverage: Contamination detection, adulteration analysis, microplastics, and authenticity verification
  • Geology: Rock and mineral identification
  • Art: Pigment identification and material composition analysis without damaging the sample!
  • Cosmetics: Raw material analysis and contamination detection

 

Empower Your Analysis with the MacroRAM Raman Spectrometer

The MacroRAM is more than just a spectrometer — it's a powerful tool that enhances your analytical capabilities, improves your workflow, and delivers reliable results.


Accessories


HPLC Flow Cell

With a sample capacity of 20 μL, this non-fluorescing fused silica cell is ideal for on-line monitoring of Raman samples. The cell maintains high sensitivity because it has a large aperture for collecting the excitation light to the sample and spontaneous Raman emission from the sample. The flat sides allow maximum throughput while keeping the scattering of the incident radiation to a minimum. In order to use this cell, the user must also have the thermostatted cuvette holder.

Standard Quartz Cuvette

With a 4-mL volume, this cell measures 10 mm × 10 mm in cross-section, and comes with a Teflon® stopper to contain volatile liquids.

Reduced Volume Cuvette and Adapter

Reduced volume cuvettes are available in 250 µL or 500 µL volumes. Each reduced volume cuvette requires an adapter to fit properly into the standard cuvette holder.

Fused Silica Cuvette

This 2-mL to 4-mL non-fluorescing fused silica cell can accept a magnetic stirrer, has a 10-mm path length, and includes a white Teflon® cap that prevents sample evaporation.

Thermostatted Cuvette Holder

The Thermostatted Cuvette Holder keeps a sample at a constant temperature from -20°C to +80°C. From 5°C to +80°C the temperature is maintained with just water. Below 5°C the temperature is maintained by an ethylene glycol/water mixture pumped through an external circulating temperature bath (not included). The holder also includes a magnetic stirrer, enabling mixing of turbid or viscous samples. For temperature measurements, the user must supply their own or purchase the Temperature Bath.

Solid Sample Holder

The Solid Sample Holder is designed for samples such as thin films, powders, pellets, microscope slides, and fibers. The holder consists of a base with a dial indicating angle of rotation, upon which a bracket, a spring clip, and a sample block rest. This holder comes standard with every MacroRAM.

Cuvette Holder

The Cuvette Holder is designed to hold standard 10 mm x 10 mm cuvettes for measurements of liquids. With additional adapters, reduced volume cuvettes or smaller cuvettes can also be placed in the Cuvette Holder. This holder comes standard with every MacroRAM.

SuperHead

The SuperHead is a high efficiency remote Raman probe which enables in situ non-invasive chemical analysis to be undertaken. The purpose of the SuperHead is to efficiently deliver the laser beam to the sample material, and to collect and filter the returning Raman signal.

The SuperHead uses a single FC/PC terminated fiber for delivering the laser excitation and another FC/PC terminated fiber for signal collection. High efficiency filters incorporated within the probe provide effective laser and Raman filtering.

The SuperHead can perform measurements in a non-contact/non-invasive mode or in an immersion mode, using specific accessories.

Temperature Bath

For studies of samples whose properties are temperature-dependent, use theTemperature Bath along with the Thermostatted Cuvette Holder (see above). The controller circulates fluids externally, with tubes leading to the sample chamber. The temperature range is from –20°C to +80°C. Sensor and all cables are included with the Temperature Bath and it is available in a 110V and 220V version.

External Probes

Various external immersion and touch probes are available to add to the MacroRAM. External probes can be easily connected to the MacroRAM for measurements outside of the sample compartment to accommodate larger or irregularly shaped samples. 


Download this macro Raman spectroscopy poster to hang in your lab


Featured Webinars

  • Industrial Applications for Macro-Raman Spectroscopy
    This webinar will focus specifically on Macro-Raman and the valuable information it can provide from identification/differentiation to quantification, to real-time process monitoring.
  • Applications in Macroscopic Raman Spectroscopy: From Industrial QC to Teaching Labs
    This webinar will provide a general overview of Raman spectroscopy and HORIBA's MacroRAM Raman spectrometer. Select applications examples and measurement demonstrations will be presented for pharmaceutical, microplastic and polymer samples.

 

Featured Videos

MacroRAM Benchtop Raman Spectrometer Video

How To Set Up Your MacroRAM from HORIBA Video

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Spectroscopy in 60 Seconds - MacroRAM Accessories and Probes Video

Spectroscopy in 60 Seconds - KnowItAll HORIBA Edition Video

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Presentation Video

 

Wavelength

785 nm

Laser Power

7 mW – 450 mW

Laser Safety

Class 1, internal sample compartment; Class 3b, external probe

Dispersion (nm mm-1)

10.3

Spectrograph f/#

3.3

Spectrograph Focal Length 

115 mm

Spectral Range

100 – 3400 cm-1 (Stokes)

Detector Type

Syncerity Back illuminated NIR CCD

Sensor Size

2048 x 70

Pixel size 

14 µm

Detector cooling

-50°C

Dynamic Range

55,500:1

CCD Dark Current (e-/pixel/s)

0.05

Spectral Resolution 

8 cm-1 at 914 nm

Dimensions (W x D x H)

432 mm (17”) x 432 mm (17”) x 381 mm (15”)

Weight

45 lbs (20.4 kg)

Ambient Temperature Range

15 – 30°C (59 – 86°F)

Maximum Relative Humidity

75%

Power

Universal AC single-phase input power; 100-240 V AC; line frequency 50 – 60 Hz

Fuses

One 5 x 20 mm IEC approved, 2.0 A, 250 V, time delay fuse

Operating System

Compatible with Windows 7, 10, and 11 (32-bit or 64-bit)

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Following Epoxy Cure with Macroscopic Raman Analysis
Following Epoxy Cure with Macroscopic Raman Analysis
Because Raman spectroscopy provides information on molecular composition, it is an ideal tool for studying chemical reactions. In particular it has been used successfully for studying polymerization where the change often involves the disappearance of a carbon double bond (>C=C<) as the polymer chain is lengthened by the addition of a monomeric group. In this note we will be looking at epoxy cure which is a reaction that causes cross-linking during the polymerization process to form a solid with fixed three-dimensional geometry.
Quantitative Analysis of Common Components in a Chemical Mechanical Polishing (CMP) Slurry Using Raman Spectroscopy
Quantitative Analysis of Common Components in a Chemical Mechanical Polishing (CMP) Slurry Using Raman Spectroscopy
In this application note, Raman spectroscopy is explored as an easier and more flexible technique for quantifying common components in a CMP slurry, such as benzotriazole and glycine, without any sample preparation or costly consumables.
Quantitative Analysis Using Raman Spectroscopy in Pharmaceutical Applications
Quantitative Analysis Using Raman Spectroscopy in Pharmaceutical Applications
Raman spectroscopy is well known as a powerful analytical method for qualitative chemical analysis. Less well known is that under certain conditions Raman spectroscopy can also be an effective method for quantitative analysis. Here we demonstrate that capability for quantitative analysis under a variety of conditions, involving different solutes in a solution and solution mixtures, and its applications to pharmaceutical analysis such as content uniformity.
Rapid Polymer Identification of Fishing Gear Using Raman Spectroscopy
Rapid Polymer Identification of Fishing Gear Using Raman Spectroscopy
Plastic pollution from fishing gear is a global problem that harms the environment. Recycling of damaged or abandoned fishing gear is one way of mitigating the issue, however the exact nature of the polymer must be known in order to identify the correct recycling stream. In this paper, the MacroRAM benchtop Raman spectrometer with remote BallProbe® is used to quickly identify plastics used in various gillnet samples. Raman spectroscopy is demonstrated to be an excellent technique for identifying not only different types of polymers, but also different variants within a polymer class and additives including pigments.

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